Browsing by Author "SALEM HUSSAIN SALEM ALHARETHI"
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- ItemRestrictedSUMOylation regulates focal adhesion dynamics in cancer cells(Saudi Digital Library, ) SALEM HUSSAIN SALEM ALHARETHI; Prof. Phil DashSUMOylation is a post-translational modification mechanism of proteins. I identified a novel role of SUMOylation in the regulation of focal adhesion proteins during cancer cell migration. I created a mutation in vinculin (FA protein) to prevent its SUMOylation and this mutation caused a significant reduction in the focal adhesions (FA) turnover rate and cancer cell migration.