Research portfolio: Quantum chemistry of phosphines, Synthesis of 5-Hydroxy-2-methoxy-4-nitrobenzaldehyde, Synthesis of a Rishirilide fragment and Evaluating the Synthesis and Biological Performance of the PET Imaging Agent [89Zr] Zr-DFO-Trastuzumab.

Abstract

The alternative research portfolio includes mainly five tasks with different requirements, where the first task is related to the computational methods to study the air stability of some primary phosphines. Accordingly, in this task, the research finding shows that there are no specific rules to decide whether the phosphines molecules are air stable or not, and the number of stable primary phosphines is very low. In regard to the second task, it is represented in the experimental methods and suggest some laboratory methods to Synthesis of 5-Hydroxy-2-methoxy-4-nitrobenzaldehyde. In regard to the task three, it is known as design and synthesis, and it includes three parts, the first part support knowing how to model the molecules using either modelling kits or Chem3D software. The second part includes skills of choosing a preferable route from three given routes to synthesis Ethyl 1-hydroxy-2,5-dioxocyclohex-3-enecarboxylate, and also involves how to calculate the overall yields of reactions and also predict the cost of used chemicals for the reaction, The last part in this task includes strategies and skills of synthesis of ( Ethyl 1-hydroxy-2,5-dioxocyclohex-3-enecarboxylate), using a good route depending on several parameters such as availability of starting materials , the cost, safety and also the time expected to be consumed. It has been used route involving enolate formation and witting reaction as a good route. Task 4 is mainly about the data analysis; it involves critical analysis of some articles about PET technique to detect the tumours. The last task is about summary for the research portfolio.