Patty Coker-BoltTurki kahild Aljuhani2022-06-012022-06-01https://drepo.sdl.edu.sa/handle/20.500.14154/59141Infants who do not succeed at early feeding are likely discharged from the nursery with a gastrostomy tube (G-tube), putting them at risk for worse neurodevelopmental and sensory outcomes than infants who achieve full oral feeds. This study aims to investigate the impact of Non-invasive transcutaneous auricular vagal nerve stimulation (taVNS) on infants' early motor development and long-term neurodevelopmental sensory performance at 18 months. Besides the observed feeding improvement using taVNS paired with bottle-feeding, we explore if pre-treatment total STEP scores' is able to predict response to taVNS intervention. The pre-treatment total STEP scores did not contribute to the prediction model significantly. Then, we looked at the long-term effect of early taVNS treatment in both neurodevelopmental and sensory outcomes at 18 months follow-up. We found that infants who responded to early taVNS treatment when paired with bottle-feeding had better overall neurodevelopmental outcomes than non-responders. We also found that responders had significantly better typical scores in the general sensory section, and had more typical average mean scores in almost all the sensory profile sections than non-responders. These preliminary results are encouraging of the use of taVNS. Future studies can include randomization of active and control taVNS intervention with larger sample size.en