Albrahim, Abdulsatar Hijy Mohammad2022-05-182022-05-182017718https://drepo.sdl.edu.sa/handle/20.500.14154/3864Carvedilol is one of the commonly used beta blockers , concomitant administration of this medicines with other medicines’ for coronary vascular disease is common , drug interaction could be a problem specially with those inhibits the cytochrome enzymes responsible for its metabolism like statins drugs. Rosuvastatin is a known inhibitor for CYP2C6 in rats that considered as a counterpart of CYP2C9 in humans that responsible for carvedilol metabolism in large extent with other enzymes as CYP2D6. TenThesis