Adibi, AliAlsaggaf, Abeer2025-12-312025https://hdl.handle.net/20.500.14154/77771Horizontal slot microdisk resonators provide a new pathway for integrated photonic sensing by combining ultra-high optical performance with strong interaction between light and analytes. In this work, a complete design and nanofabrication process was developed to realize these devices, which were validated through chemical and biomolecular sensing experiments. The approach demonstrated reliable detection of both refractive index changes and surface-adsorbed biomolecular layers, including the clinically relevant biomarker Troponin I. These results highlight the horizontal slot architecture as a powerful platform for lab-on-chip technologies with applications in healthcare diagnostics, environmental monitoring, and portable point-of-care systems.116en-USwhispering gallery modesphotonic sensorssilicon photonicshorizontal microdiskchemical sensinglight-analyte interactionlab-on-chipphotonic micro-cavityThesis