Dr Mohammed AhmedMOHAMMED HUSSAIN AHMED ALNASHRI2022-05-282022-05-28https://drepo.sdl.edu.sa/handle/20.500.14154/37686Results showed that expressions of miR-148a and K1 are enhanced in keratinocytes in vitro in response to calcium levels. MiRNA-148a can help in therapy to treat various diseases concerning the skin and appendages while also functioning as a prognostic and predictive marker for diagnosing skin cancer. It was not possible to determine upregulated miRNA-148a’s target genes in keratinocyte differentiation, and thus, further studies must be conducted to identify how miRNA- 148 affects keratinocyte differentiation.en