AHMED, AKRAMELBANNA, RANAAL JARAH, ABDULRAHMAN2025-07-232024-09-10https://hdl.handle.net/20.500.14154/75939Background: Renal rehabilitation is a multimodal, coordinated intervention aimed at improving a patient's physical, psychological, and social functioning. Additionally, a growing body of research indicates that exercise training improves left ventricular function, cardiac sympathetic and parasympathetic disharmony, as well as Vo2 max in hemodialysis patients. Purpose: To systematically summarize the randomized controlled studies and investigated the effect of comprehensive renal rehabilitation in hemodialysis. Data source: Four electronic data base (PubMed, Pedro, Cochrane and Google scholar) were searched from 2014 till 2024. Study selection: Two independent reviewers screened studies for eligibility first by title then by title then by abstract then finally full text. Data extraction: Fourteen studies met the inclusion criteria of this review, all of them were about comprehensive renal rehabilitation in hemodialysis studies quality was assessed using Pedro and the Cochrane risk of bias assessment tool. Data synthesis: Fourteen studies were included in the quality assessment, studies were of good quality while the rest were fair quality on the Pedro scale, studies state that. Results: Met-analysis showed that there was significant effect of comprehensive renal rehabilitation in hemodialysis in the outcome measurers (Fatigue level, Vo2 max, muscle strength, physical, mental function and blood pressure change). Conclusion: This analysis showed that there were effects of comprehensive renal rehabilitation in hemodialysis130en-USRenal rehabilitationHemodialysisPhysiotherapist at King Khaled HospitalThesis