Anne Rowat & Lisa KiddHADEEL AHMED ALAWLAH2022-05-292022-05-29https://drepo.sdl.edu.sa/handle/20.500.14154/44340Abstract Background Recent statistics shows that colorectal cancer is the third common cancer which cause mortality and morbidity among male and female. The major challenge with colorectal cancer treatment is inadequate pain management which interferes with patient’s quality of life. Previous review including colorectal cancer populations show significant effect of physical exercise on quality of life improvement, fatigue, and depression. Therefore, it is crucial to develop a review to support the use of exercise in pain management for patients with colorectal cancers. Method A systematised review was conducted using the (PRISMA) model. The databases MEDLINE, CINAHL, and EMBASE were used to identify andomized control trials that assess the effect of physical exercise on colorectal cancer-related morbidities including pain, published between 2011-2021. Included studies was assessed by Cochrane risk of bias tool. Narrative description carried out to discover the main findings. Result A total of 5 two-armed RCTs with total of 182 colorectal cancer patients were included. The interventions were either unsupervised home-based or supervised hospital-based exercise programs compared to usual activity. The findings indicated that physical exercise was effective in reducing pain levels in 3 (60%) of the included studies, while no significant pain level differences in 2 (40%) studies. Conclusion While three of the studies indicates that exercise can be used as a non-pharmacological intervention for pain management in colorectal cancer patients. However, future research should focus on improving the current evidence on the use of exercise for pain management in patients with colorectal cancer. Dissemination Colorectal cancer surgery conference & social media platforms.en