Rutten, BartAl Jowf, Ghazi Ibrahim Abdurahman2023-10-092023-10-092023-05https://hdl.handle.net/20.500.14154/69352This thesis aims to address the gaps of knowledge in the understanding of the association between epigenetic mechanisms, gene activity, and differential susceptibility to PTSD. It also aims to identify the public health measures that can be effectuated for the prevention of PTSD and how biomarkers may support these measures. Accordingly, the thesis discusses the possible ways that can aid in the early identification and detection of PTSD resulting from traumatic stress, and the possibility of developing biomarkers of increased susceptibility. It also discusses how this early detection can help with early intervention, and if early enough, prevention. Application of such models, with findings from future research to establish cost-effective measures, can greatly enhance the patient’s quality of life and decrease the disease burden.Traumatic stress exposure can induce the development of mental disorders such as post-traumatic stress disorder (PTSD), resulting in a decreased quality of life and increased disease burden. This thesis investigated and addressed the gaps of knowledge in the understanding of the association between epigenetic mechanisms, gene activity, and differential susceptibility to PTSD. It also identified the public health measures that can be effectuated for the prevention of PTSD and how biomarkers may support these measures. Accordingly, it discusses the possible ways that can aid in the early identification and detection of PTSD resulting from traumatic stress, and the possibility of developing biomarkers of increased susceptibility. It also discusses how this early detection can help with early intervention, and if early enough, prevention. Application of such models, with findings from future research to establish cost-effective measures, can greatly enhance the patient’s quality of life and decrease the disease burden.240enPublic HealthPTSDTraumatic StressEpigeneticsPreventionThesis