Browsing by Author "Algomizy, Hamza"
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- ItemRestrictedNitric Oxide Levels in Association with Lipid Profile in Endothelial Dysfunction among Type 2 Diabetic Patients(Saudi Digital Library, 2021) Algomizy, Hamza; Mohieldein, Abdelmarouf Hassan; Khan, Amjad AliSaudi Arabia is one of the leading countries that have a higher prevalence of diabetes, which represents 23.9% of the total population. Individuals with type 2 diabetes have the chance to develop coronary artery disease (CAD) four-folds more than healthy individuals. CAD in early-stage diabetic patients is often asymptomatic and slow in progression, this imperative situation of silence and asymptomatic incidence requires evidence and screening procedures to verify myocardial ischemia onset in diabetic patients with high susceptibility to develop CAD. This study aimed to (1) estimate the level of NO in association with lipid profile, (2) figure out lipid profile indexes and atherogenic index of plasma (AIP), (3) find the correlation between levels of NO and selected independent variables in type 2 diabetic patients with CAD compared to diabetic patients without any complications and to healthy donors. A case-control study in which a total of 103 people have participated, included 50 diabetic patients with diagnosed CAD (group 1; case), 30 diabetic patients without documented CAD or other diabetes complications (group 2; control 1), and 23 healthy controls where they are neither diabetic nor CAD (group 3; control 2). Biochemical parameters were determined as per standard procedures, while Plasma NO was determined quantitatively by measuring its products nitrite and nitrate. Data analyzed using SPSS; descriptive statistics used for demographic and clinical variables. Comparison of variables between groups performed with an unpaired T-test. Pearson correlation was used to examine the relationship between plasma nitric oxide level and selected independent variables. Significance was considered when a P- value was less than 0.05. Data analysis revealed that the cases (group 1) showed significantly high levels of plasma nitric oxide compared to diabetics without complications (P=0.013) or healthy subjects (P=0.011). NO was positively correlated to FBS and HbA1c but negatively correlated to TC. Chronic hyperglycemia is possibly accountable for the induction of the endothelial cell for NO overproduction, which may be considered as a key mediator for the incidence of diabetes-related endothelial dysfunction and vascular complications progression.