Browsing by Author "Alenizi, Dalal"

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The Eosinophil Response to Gastrointestinal Teladorsagia circumcincta Nematode Infection
(La Trobe University, 2024-02) Alenizi, Dalal; Stear, Michael
The aim of this thesis is to investigate the role of eosinophils in host defense against gastrointestinal nematode infections in sheep and goats with a particular focus on Teladorsagia circumcincta (T. circumcincta). Larval stages of T. circumcincta develop on the gastric mucosa, compromising nutrient absorption from the gastrointestinal tract, so infected animals have impaired growth, weight loss, and, in some cases, may die. Eosinophils and IgA appear to regulate worm growth and fecundity; they have been associated with resistance mechanisms associated with larvae. Goats are more susceptible than sheep to gastrointestinal worms. We compared nucleotide sequences and predicted the protein sequences of key eosinophil proteins between goats and sheep. We observed that nitrosylated tyrosine plays a key role in sheep EPX but is absent in goat EPX, which is important for post-translational nitration of eosinophil secondary granule proteins, which may influence protective responses.
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