Browsing by Author "Alhazmi, Rawan"

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Characterization of Age- and Sex-Specific Metabolic Pathway Alterations in the Colon Associated with CRC Development
(Saudi Digital Library, 2024) Alhazmi, Rawan; Derer-Petersen, Stefanie; Gottschild, Clarissa
Both age and sex are important factors influencing metabolic processes, impacting energy production, immune regulation, and lipid metabolism. Metabolic efficiency usually declines with age, leading to dysregulation of key metabolic pathways, which could lead to different health issues such as chronic inflammation and cancer. These age-related changes are affected in both sexes differently, with males and females experiencing distinct metabolic shift patterns due to their biological differences, such as sex hormones. Investigating these variations could help clarify how age- and sex-specific metabolic shifts elevate health risks. Therefore, a proteomic analysis was used to filter proteins from C57BL/6J mice of different ages and sexes based on their involvement in metabolic processes, and then through statistical analysis, significantly up-regulated or down-regulated proteins were identified. STRING network analysis was employed to identify key metabolic pathways enriched in these regulated proteins. Notably, pathways related to lipid metabolism, such as fatty acid oxidation and lipid transport, were highly enriched in up-regulated protein, particularly in older male mice, suggesting an age-related shift toward lipid utilisation. Down-regulated proteins were primarily associated with amino acid metabolism across sexes, though with distinct patterns. Among the proteins involved in enriched pathways, four proteins were observed in multiple enriched pathways. CD36, FABP4, HMGCS2, and KYAT3. These metabolic shifts are closely tied to the development and progression of colorectal cancer (CRC). CRC incidence increases with age, and men are generally at higher risk than women. Metabolic dysregulation, including lipid accumulation, impaired energy metabolism, and a weakened immune response, has been strongly linked to CRC. These processes not only facilitate the growth and proliferation of cancer cells but also create a tumour-friendly environment in an ageing colon. Therefore, monitoring these metabolic alterations could provide insights into potential biomarkers for early CRC detection.
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Factors Influencing mHealth Acceptance: An Empirical Investigation from a Trust-Anxiety Perspective
(Saudi Digital Library, 2023-11-23) Alhazmi, Rawan; Dong-Ling, Xu; Yu-Wang, Chen
Mobile health (mHealth) is an emerging healthcare technology designed specifically for improving individuals’ quality of life. Despite mHealth purported benefits, its acceptance rates have fallen short of industry expectations. Lack of trust and anxiety have been identified as two long-term barriers to successful mHealth acceptance. Yet, little attention has been devoted to understand individuals’ acceptance of mHealth services from a trust and anxiety perspective in the current mHealth acceptance research. The virtuality of mHealth services and the sensitivity of health data are two major issues affecting individuals’ acceptance of mHealth services before the initial interaction stage with the service. In such situations, trust in mHealth service, trust in mHealth service provider, and mHealth use anxiety become central parts of the acceptance decisions formed around the use of mHealth services. Motivated by this fact, this study develops a trust-anxiety model to understand individuals’ acceptance behavior of mHealth services. The developed model draws on innovation attributes (trialability, visibility, relative advantage, and ease of use), external and interpersonal social influence, and facilitating conditions from information systems, innovation diffusion, and social psychology research to understand the factors affecting individuals trust and anxiety when accepting mHealth services from social, technological, and behavioral dimensions. The developed model was empirically validated via a sample of 385 potential adopters in Saudi Arabia and 507 in the United Kingdom using online self-administrated surveys. Partial least squares structural equation modeling was used to assess the developed research model. The findings in Saudi Arabia and the United Kingdom showed that potential adopters mHealth acceptance was largely promoted by their level of trust in mHealth service followed by their level of trust in mHealth service provider. The results further indicated that in the United Kingdom, mHealth use anxiety can significantly reduce potential adopters’ acceptance of mHealth services. Moreover, the results in Saudi Arabia and the United Kingdom showed that trialability can increase individuals mHealth use anxiety, while ease of use can significantly reduce it when accepting mHealth services. However, in Saudi Arabia, the results further showed that trust in mHealth service can significantly reduce potential adopters mHealth use anxiety when accepting mHealth services. The results also suggested that trust in mHealth service can be promoted by relative advantage, ease of use, interpersonal social influence, and trust in mHealth service provider in both countries before the initial interaction stage with the service. On the other hand, the results revealed that trust in mHealth service provider was positively affected by external social influence, relative advantage, facilitating conditions, and visibility in Saudi Arabia. However, in the United Kingdom, trust in mHealth service provider has been found to be positively associated with external social influence, facilitating conditions, and relative advantage. From a theoretical perspective, this study contributes to existing mHealth acceptance literature by providing a comprehensive understanding of mHealth acceptance behavior from a trust-anxiety perspective. From a practical perspective, the study offers valuable information for mHealth participants that can help them in promoting their mHealth services acceptance rates.
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