Browsing by Author "Alkhawajah, Batool"

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The therapeutic role of Non-invasive Temporal Interference (TI) stimulation in Traumatic Brain Injury
(Imperial College London, 2024) Alkhawajah, Batool; Sastre, Magdalena; Hervas, Laura Abelleira
The therapeutic role of Non-invasive Temporal Interference (TI) stimulation in Traumatic Brain Injury Traumatic Brain Injury (TBI), characterized by cranial compression leading to neural loss and white matter damage. IT is associated with the development of severe neurological disorders such as Alzheimer's and dementia. Temporal interference (TI) stimulation has emerged as a recent therapeutic modality for severe neurological and psychiatric disorders, such as Alzheimer's disease (AD) and dementia. TI stimulation delivers two frequencies to the brain, generating an electrical field with nuanced frequency differentials, thereby non-invasively targeting specific brain regions. Experimental validation on animal models and healthy subjects has revealed significant improvements in cognitive function following TI stimulation. Recognizing shared pathological mechanisms between TBI and AD, our laboratory has initiated investigations into the potential anti-inflammatory effects of TI stimulation in the context of TBI. A conducted experiment applied TI stimulation targeting the ipsilateral hippocampus in a mild Closed head injury (CHI) model, with a single impact, resulting in observed memory enhancement. However, the cellular and molecular consequences of TI stimulation on the brain remain an unexplored realm. This research project seeks to delineate these changes through various staining techniques targeting Glial Fibrillary Acidic Protein (GFAP), microglia, and neurogenesis. Floating brain sections from three distinct groups: CHI-TI, CHI control, and sham were subjected to staining, enabling the quantification of alterations in the hippocampal region and cortex. Our findings unveil that TI stimulation augments activated microglial populations, diminishes astrocyte presence, and exerts no apparent impact on neural proliferation. This scientific endeavour contributes to the elucidation of the neurobiological effects of TI stimulation, paving the way for a deeper understanding of its therapeutic potential in TBIs.
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