Browsing by Author "Alshammari, Jamilah"

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IL36 and IL37Cytokines, Mediators or Potential Modulators of Airway Infection and Inflammation?
(Saudi Digital Library, 2022-10-01) Alshammari, Jamilah; Flannagan, Brian
Respiratory tract infections caused by viruses or bacteria are among the most common human diseases worldwide. More specifically, respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infection (ALRI), and this frequently results in hospitalisation in young children, particularly among those under the age of 5, and the elderly. Infection with RSV is also correlated with various airway respiratory diseases, such as bronchiolitis and asthma. In vivo testing suggests that levels of IL-36 alpha, IL-36 gamma, and IL-37 protein can be very high in nasopharyngeal aspirate (NPA) during RSV and rhinovirus (RV) infections. This work thus hypothesises that, during RSV and RV infections, the epithelial cells in the airways may express IL-36α, IL-36γ, and their respective receptors in a manner that plays a crucial pro-inflammatory role in RSV and RV infections. In addition, this work hypothesises the possibility of the further expression of IL-36Rα and IL-37 cytokines by airway epithelial cells (AECs) in response to RSV and RV infections. The main aim of this work, as described in this thesis, is thus to investigate whether RSV infection can trigger AECs to express IL-36 and IL-37 cytokines and their receptors.
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