Browsing by Author "MOHAMMED SALEH OBAED ALFAWAZ"

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Cytogenetic analysis of spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) Lymphoblastoid Cell Lines
(Saudi Digital Library) MOHAMMED SALEH OBAED ALFAWAZ; Dr. Adam Hodgson
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The Relevance of Chromosome 6 to Uveal Melanoma: Relationship to Prognosis and Identification of Possibly Candidate Driver Genes
MOHAMMED SALEH OBAED ALFAWAZ; Dr. Karen Sisley
Uveal melanoma (UM) is the most common primary intraocular disease of adults and has a high mortality rate compared to other melanomas. Non-random chromosomal aberrations have been associated with UM, such as monosomy 3, gain of chromosome 8q, loss of chromosome 1p and gain of chromosome 6p and loss of 6q (isochromosome 6p). Monosomy 3 and gain of chromosome 8q have the strongest association with poor prognosis for UM. That said, although structural aberrations of chromosome 6 have been detected in some studies of UM, the alterations in this chromosome have been underestimated, possibly because of the focus on other chromosomes or the use of classical technologies such as karyotyping and comparative genomic hybridisation (CGH). This thesis, therefore, will look to identify candidate genes on altered chromosome 6 that may contribute to the development, prognosis and metastasis of UM. This thesis aims to associate different alterations of chromosome 6 with the known genetic mutations in UM. In order to achieve this, the aberrations within chromosome 6 will be analysed in detail using a specifically designed high-resolution array-CGH for UM in order to determine candidate genes that have an association with UM. Ultimately, these candidate genes will be explored using various technologies to corroborate their effect on the UM.
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