Browsing by Author "MOHSEN ABDULLAH MOHSEN ALAMOUDI"
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Item Restricted Synthesis, Characterization and Biological Evaluation of Fluorinated Heteroaromatic Chalcone AnaloguesMOHSEN ABDULLAH MOHSEN ALAMOUDI; Ian HardcastleSeveral fluorinated heteroaromatic chalcone derivatives in a number of eleven compounds involving the parent chalcone 4a and 10a – 10j were synthesized, isolated, and characterized. The diversity in these compounds involved the change in Ring A by incorporating fluorine atoms in the different positions (ortho, meta, and para), besides transforming the heteroaromatic rings involving pyridine, thiophene, methyl thiophene, and furan. The derivative’s structures were confirmed by the different NMR techniques, IR, and X-ray crystallography for some of the compounds. Then, a disk agar diffusion test was performed to measure the antimicrobial activity for some compounds against E. coli, S. pombe.0 0