Browsing by Author "Mohammed, Mohammed Salem Moqbel"

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Toxicopathological studies on the effects of Momordica Charantia in normal and diabetic rats
(Saudi Digital Library, 2016) Mohammed, Mohammed Salem Moqbel; AL-Hizab, Fahad Abdullah
The present study was conducted to evaluate the clinicopathological effects of Momordica Charantia in normal and streptozotocin (STZ)- induced diabetic male Wistar rats. Momordica Charantia is claimed to have several medicinal properties and is used as a traditional medicine for the treatment of a wide variety of disorders. In this study the powdered whole fruits of Momordica Charantia was fed to normal and STZ- induced diabetic rats at 2, 5 and 10 % of the standard diet for a period of 3 months. In normal rats, the administration of Momordica Charantia fruits at 2 and 5 % was not toxic. However, individual cell necrosis and degenerative changes in hepatocytes and in renal tubules were observed in rats fed with a diet containing 10% Momordica Charantia. No changes were observed in pancreatic tissue in all rats. These histopathological changes were accompanied clinically by significant alterations of AST, ALT, ALP, BUN, creatinine and uric acids. The blood glucose concentrations were decreased approximately to 50% in rats fed 5 and 10% Momordica Charantia . In streptozotocin (STZ)-induced diabetic rats, the administration of Momordica Charantia fruits at 2, 5 and 10% generally alleviated the lesions in liver, kidney and pancreatic tissues normally associated with diabetes. Dose-dependent recovery involving cytomegalic hepatocytes, renal tubular vaculations and pancreatic islets degeneration and necrosis were seen. However, in rats given 10% Momordica Charantia individual hepatocytic and renal tubular necrosis were observed. In addition, a significant dose-dependent reduction of AST, ALT, ALP, cholesterol, BUN, creatinine and uric acid were observed in all rats. The blood glucose concentrations were significantly decreased in rats given 5% and 10% of Momordica Charantia. Moreover, all treated diabetic groups showed II significant gradual recovery from anemia indicated by improved hematological values. In conclusion, Momordica Charantia fruits given at 5% and 10% of the daily standard diet for 3 months seem to posses hypoglycemic effects on normal and diabetic rats through alleviations of tissues injury and improvement of hematological and serobiochemical parameters. However, the administration of Momordica Charantia fruit at 10% of the daily standard diet for 3 months showed mild hepatotoxicity and nephrotoxicity in normal and diabetic rats
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