Browsing by Author "Alsharif, Ola"

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Ibn Saud's foreign policy towards Great Britain and Italy during 1932-1945: a comparative analysis.
(Newcastle University, 2025) Alsharif, Ola; Berridge, Willow
This research provides a comparative analysis of Saudi international relations under Ibn Saud (1880-1953), focusing on the interactions with Britain and Italy. By examining these cases, the study offers a political perspective on the history of modern Saudi Arabia and its role in international politics, emphasizing the autonomy and diplomatic skills of King Abdulaziz. While Western historiography often attributes Ibn Saud’s rise to power primarily to British interests in the Middle East, this thesis seeks to uncover the internal and international forces that were crucial in consolidating his power and the Al-Saud dynasty. It aims to provide a more nuanced understanding of King Abdulaziz as an independent political figure who strategically navigated the complexities of international relations to secure his position and the sovereignty of his kingdom.
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Ibn Saud's foreign policy towards Great Britain and Italy during 1932-1945: a comparative analysis.
(Newcastle University, 2024) Alsharif, Ola; Berridge, Willow
This research provides a comparative analysis of Saudi international relations under Ibn Saud (1880-1953), focusing on the interactions with Britain and Italy. By examining these cases, the study offers a political perspective on the history of modern Saudi Arabia and its role in international politics, emphasizing the autonomy and diplomatic skills of King Abdulaziz. While Western historiography often attributes Ibn Saud’s rise to power primarily to British interests in the Middle East, this thesis seeks to uncover the internal and international forces that were crucial in consolidating his power and the Al-Saud dynasty. It aims to provide a more nuanced understanding of King Abdulaziz as an independent political figure who strategically navigated the complexities of international relations to secure his position and the sovereignty of his kingdom.
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Mechanisms of Nur77 in Health, Disease, and Therapeutic Potential
(University College London, 2024-08-28) Alsharif, Ola; Rombouts, Krista
The orphan nuclear receptor Nur77 (NR4A1) (TR3) (NGFI-B) plays an important role in liver physiology, regulating key processes such as metabolism and inflammation, and impacting the development and management of diseases like non-alcoholic fatty liver disease (NAFLD), fibrosis, and hepatocellular carcinoma. This review provides a comprehensive exploration of Nur77's structure, functions, and mechanisms of action in different organs and diseases, with a particular focus on its roles in liver health and disease. Nur77 acts as both a transcription factor and a cytoplasmic signalling molecule, regulating glucose and lipid metabolism, inflammation, and apoptosis. Recent research highlights Nur77's involvement in liver regeneration and repair, as well as its dual roles in tumour suppression and tumour promotion. Additionally, Nur77 is implicated in different organ-related diseases. These include cardiovascular diseases (cardiac hypertrophy and apoptosis), neurological diseases (affecting neuroprotection and neural injury), and metabolic disorders such as obesity and diabetes. This review explores Nur77's interactions with key signalling pathways and its potential as a therapeutic target. Evidence suggests that pharmacological activation or inhibition of Nur77 could offer new approaches for treating liver fibrosis, metabolic disorders, and liver cancer. However, the context-dependent nature of Nur77's effects presents both opportunities and challenges for drug development. This review seeks to deepen our understanding of Nur77's roles in liver pathophysiology and to identify research gaps for further investigation. By synthesising current knowledge and recent advances, this review contributes to the growing body of literature on Nur77 and provides a foundation for future studies exploring its potential as a therapeutic target in liver diseases.
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