Browsing by Author "Alzahrani, Faisal"

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Assessment of Minimal Residual Disease in Patients with B-Cell Acute Lymphoblastic Leukaemia using Euroflow: Relation to Other Risk Factors
(Imam Abdulrahman Bin Faisal University, 2021) Al-Qhatani, Samirah Mushbab; Gameel, Fathelrahman Mahdi Hassan; Alzahrani, Faisal
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Frequency of UCP2 45bp Insertion/Deletion Polymorphism in Diabetic and Non-Diabetic individuals in Eastern Province of Saudi Arabia
(Imam Abdulrahman Bin Faisal University, 2017) Al-Omairi, Amani Abdulmohsin; Alzahrani, Faisal
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PLATELET CONCENTRATES AND ARTHROCENTESIS AS A THERAPEUTIC OPTION FOR TEMPOROMANDIBULAR JOINT OSTEOARTHRITIS: A SYSTEMATIC REVIEW OF SYSTEMATIC REVIEWS
(Ulster University, 2024) Alzahrani, Faisal; Issa, Sally; Seoudi, Noha
Abstract Aims/Purpose This systematic review of systematic reviews (SR of SRs) investigates the efficacy of intra-articular injections (IAIs) of platelet-rich concentrates (PCs) combined with arthrocentesis for managing temporomandibular joint osteoarthritis (TMJ OA). The comprehensive analysis compares the effectiveness of PCs combined with arthrocentesis to hyaluronic acid (HA), corticosteroids (CS), arthrocentesis alone, and placebo in reducing pain and improving maximum mouth opening (MMO). Methods Comprehensive database searches were performed in PubMed, Scopus, Cochrane Library, and Google Scholar, studies from 2012 to 2023, with the final search conducted in December 2023. Studies were critically appraised using the Critical Appraisal Skills Programme (CASP) and Risk of Bias in Systematic Reviews (ROBIS) to ensure rigorous evaluation. Results The search identified 74 articles, with 17 meeting the inclusion criteria after deduplication and screening. An additional three studies were found through manual reference list searches. Overall risk of bias in the reviews showed 39% of the studies had a low risk of bias, 44% showed a high risk, and 17% were unclear. While a significant proportion of the studies showed a low risk of bias in some areas, high and unclear risks were also prevalent across various aspects of the reviews. Conclusion The SR of SRs demonstrates the strong potential benefit of PCs with arthrocentesis in reducing the pain of TMJ OA and provides guidance for future research to address the shortcomings of current trials. While the quality of the evidence varies, the positive outcomes highlighted warrant further investigation. Future research with standardised protocols and robust methodologies is crucial to definitively assessing the effectiveness of PCs with arthrocentesis in TMJ OA treatment. This review paves the way for advancements in managing TMJ OA and invites further exploration in this promising field.
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Qualitative research to explore coping strategies, mental health and well-being following recovery from diagnosed COVID-19 in students living away from home.
(Saudi Digital Library, 2023-11-14) Alzahrani, Faisal; Rance, Jaynie
Universities are academic spaces and also function as arenas for personal growth and self- discovery. However, during the COVID-19 pandemic, university students living away from home suffered, and there is a lack of research depicting their long-term recovery process. Therefore, the current qualitative study explored the experiences of university students who contracted and recovered from COVID-19 while residing away from their families. In order to explore this, the research adopted a qualitative research design and conducted semi- structured interviews with ten participants. The data was coded and analyzed using thematic analyses. The data revealed four themes consisting of Communication, Adjustments, Spiritual Well-Being, and Mental Well-Being. The results show that Internet communication networks helped individuals feel less isolated by bridging physical distances. While making lifestyle changes to combat isolation and academic stress, spiritual and artistic pursuits offered mental comfort. Furthermore, the first shock of diagnosis elicited a range of emotional reactions, such as worry and dread, highlighting the significance of comprehending passive coping mechanisms. In contrast, recovery involved using proactive, constructive tactics. These revelations have implications for academic institutions, mental health professionals, decision- makers, and students, directing the creation of more efficient support systems for people dealing with health crises away from home
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The Association Between Risk Factors and Red Blood Cells Alloimmunization in Sickle Cell Disease Patients in the Eastern Region in a Single Centre Study
(Imam Abdulrahman Bin Faisal University, 2021) Albasri, Laila Hassan; Alzahrani, Faisal
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The Association Between Two Genetic Polymorphisms in ITGB3 and Increase Risk of Venous Thromboembolism in Cancer Patients in Eastern Province of Saudi Arabia
(Imam Abdulrahman Bin Faisal University, 2020) Al Sulaim, Asma Yousef; Alzahrani, Faisal
Background: E. coli O157 is the most remarkable of the five known diarrheagenic E. coli (DEC). The global spread of E. coli O157:H7 among children has caused the Food and Agriculture Organization of the United Nations (FAO/UN) to improve standards for food security and quality. This bacterium is the most notorious because its potentially harbors virulence genes, which can result in kidney failure, particularly hemolytic uremic syndrome (HUS).Aims: This study aims to investigate the presence of E. coli O157 in imported frozen beef marketed in Saudi Arabia by using immunomagnetic beads, multiplex-PCR, and ERIC-PCR DNA fingerprinting.Methods: In this study, 201 imported frozen beef samples were purchased from different supermarkets in the Eastern Province of Saudi Arabia. All samples were analyzed by using immunomagnetic beads (IMB), CHROMagar O157, and SMAC agar. Virulence gene markers (stx-1, stx-2, and eae) were screened by using multiplex-PCR. ERIC-PCR DNA fingerprinting was used to identify the clonal relationship among the strains isolated from different countries.Results: The overall occurrence rate of presumptive E. coli was 43.8% in examined samples, obtained by using chromogenic agar without IMB and yielding 89 isolates. In chromogenic agar with IMB, the overall occurrence rate was 52.7% in examined samples from India, Australia, Brazil, and New Zealand, with a yield of 111 isolates. Three isolates were found to be positive for the stx-1 gene while no single isolate was detected for the stx-2 and eae genes among presumptive isolates that were recovered on SMAC agar without IMB. Meanwhile, on SMAC agar with IMB,xix8 isolates were found to be positive for the stx-1 gene in samples that were imported from Australia, India, and Brazil. No samples were positive for eae from New Zealand. The highest isolates harboring the stx-1 gene were detected in beef samples imported from Australia, for which the stx-1 gene was detected in 9 isolates out of 89 recovered on chromogenic agar without IMB. Two isolates were detected for the eae gene in beef samples imported from India, while no single isolate was detected for the stx-2 gene. The overall distribution rate of the stx-1 gene among the presumptive isolates of E. coli O157 which were examined from imported frozen beef were positive in 37 (12.4%) out of 298 isolates. The stx-2 gene was detected only in a single sample from Brazil and New Zealand. ERIC-PCR primers generated different DNA polymorphisms among 42 isolates of E. coli pathotypes and were able to group all confirmed 42 isolates of E. coli into 4 clusters (A, B, C, and D) by using the UPGMA algorithm and gel J software. Therefore, 85.7% of E. coli pathotype isolates were typeable with ERIC-PCR, while 14.3% produced a single cluster. ERIC-PCR was able to group all strains according to their countries of origin except for one isolate of Australian beef, which was grouped with E. coli isolates from Indian beef. In addition, one isolate of Brazilian beef was grouped with E. coli isolates from Australian beef.Conclusion: This study confirmed that the imported frozen beef marketed in the Eastern Province of Saudi Arabia was harboring virulence gene markers of E. coli O157. The used methods of IMB and multiplex-PCR proved to be more reliable and adequate for the detection of E. coli O157 in imported frozen beef. This study recommends that food authorities such as the Saudi Food and Drug Authority (SFDA) set adequate measures to monitor imported frozen beef.
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