Saudi Cultural Missions Theses & Dissertations
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Item Restricted Benchmarking Gene Therapies for Sickle Cell Disease in Saudi Arabia Using Mendelow’ s Stakeholders Matrix(University College London, 2024-08-28) Alajmi, Reem; Nieroda, MarzenaAim and Methods: This paper explores the potential of GTs for SCD in KSA, addressing their applicability, accessibility, and comparison with traditional treatments. It aims to benchmark GTs in KSA by analysing advancements in R&D, developing equitable distribution strategies, and comparing real-world data. A scoping review was conducted using major academic databases, with 29 relevant articles selected to assess the effectiveness and implementation of SCD GTs in KSA and globally. Findings: Traditional treatments for SCD have long relied on blood transfusions and pharmacologic options like HU, approved by the FDA in 1998. While these treatments have been essential, their limitations have led to the development of new therapies, including GTs. GT offers a curative approach by targeting the genetic root of SCD. Recently, FDA-approved gene therapies, such as Casgevy and Lyfgenia, have marked a significant advancement. These therapies use innovative genome editing techniques to replace defective cells. Although promising, the adoption of GT is tempered by concerns about cost, accessibility, and long-term efficacy compared to traditional treatments, which remain widely used due to their established effectiveness and broader availability. Practical Implications: GT has the potential to revolutionize SCD management, but challenges like accessibility, affordability, and infrastructure readiness, particularly in Saudi Arabia, require comprehensive policy reforms and supportive systems for successful implementation.46 0Item Restricted Towards a feminist interpretation of female roles in early modern society: Examples from William Shakespeare's tragedies such as Hamlet, Othello, and Macbeth(Saudi Digital Library, 2023-12-01) Alajmi, Reem; Durrant, Michael; Radulescu, RalucaThis dissertation aims to explore the roles and the representation of women in William Shakespeare's tragedies through a feminist critical framework. The texts under study in this research will include three of Shakespeare’s most well-known tragic play texts: Hamlet, Othello and Macbeth. Specifically, this dissertation aims to investigate the role of women in the plays and how they enable us to understand the role of women in the early modern England through this literary lens. The first section offers a general introduction to the overall argument and the critical and theoretical background of this study. The introduction also includes the research aims, research questions, the definition of terms, the theoretical frame for analysis in this research and the importance of the study and the review of related literature. The second section shall include the research method. The third chapter shall include the analysis of female roles in Othello, the fourth chapter shall focus on female roles in Hamlet, the fifth chapter shall focus on female roles in Macbeth.34 0