Saudi Cultural Missions Theses & Dissertations
Permanent URI for this communityhttps://drepo.sdl.edu.sa/handle/20.500.14154/10
Browse
1 results
Search Results
Item Restricted Fabrication and evaluation of bilayer mucoadhesive buccal films containing lidocaine IN-VITRO Study(Queen Mary University of London, 2024) Alghamdi, Abdulaziz; Mangala, PatelBackground: The topical route can be the first line in treating most oral lesions. It offers a faster effect through direct contact with the lesions and protects the patient from unnecessary systemic absorption of chemicals with the oral route. Additionally, topicals take maximum benefits from drugs by preventing the extensive biotransformation of the drugs via the hepatic first pass. The drawback of conventional topical vehicles is the short resident time; the saliva washout shortens the contact time ,which decreases the efficacy. The aim of this project is to create optimal polymeric bilayer mucoadhesive buccal films incorporating 5% lidocaine hydrochloride (LDC HCL) (weight-to-weight ratio of the polymer) to potentially relieve pain from mucosal lesions for buccal administration. Materials and method: The delivery system was made by two layers, mucoadhesive releasing layer which made by range of polymers in different ratio (HPMC K15M, HPMC K4M and PVP) and protective backing layer were made by EC to ensure unidirectional release. The films were made in mono and bilayer, drug free and drug loaded. Additionally, the system was evaluated by measuring the water uptake behaviour, folding endurance, drug content, drug release, FTIR and XRD. Results: fabricated films were smooth, translucent and they had no visible defects. The film thickness was within the ideal thickness of mucoadhesive buccal delivery systems according to literature. Maximum swelling index for HPMC K4M monolayer films reached ~ 828 % at 25 minutes, introducing PVP to the film decrease and accelerate the swelling, maximum swelling reached ~ 741 % at 15 minutes. Adding hydrophobic layer (EC) results in dramatic decrease in swelling by 625 % and 546 %, for HPMC and HPMC + PVP monolayer films, respectively. Moreover, EC layer slow down water sorption, as the maximum swelling reached at 90 minutes for HPMC films, and it extend the swelling of HPMC + PVP films to achieve maximum swelling at 45 minutes. Conclusion: the fabricated novel delivery system showed promising results and it can be a better effective alternative for topical analgesics delivery.19 0