Saudi Cultural Missions Theses & Dissertations
Permanent URI for this communityhttps://drepo.sdl.edu.sa/handle/20.500.14154/10
Browse
2 results
Search Results
Item Restricted A systematic review of the nutritional and medical outcomes of the use of fibre containing enteral feeds vs fibre-free feeds in adults patients receiving enteral feeding(University of Nottingham, 2024-09) Albaqami, Khulud; Musson, JaneBackground: Enteral nutrition (EN) involves administering a fully balanced nutritional feed through a tube into the stomach, duodenum, or jejunum but it can lead to complications like diarrhoea, constipation, vomiting, and other gastrointestinal symptoms. Recent studies have investigated how fibre containing formulas impacts GI symptoms and clinical outcomes ; however, the findings have been inconsistent. Aim: This systematic review aimed to evaluate the outcomes associated with fibre-containing versus fibre-free feeds in adult patients receiving enteral feeding. This includes evaluating gastrointestinal symptoms (diarrhoea, constipation, abdominal distention, vomiting, regurgitation, and other GI symptoms), length of hospital stay, nutritional intake, and infectious complications. Method: A systematic search across three databases (PubMed, MEDLINE via Ovid, and Web of Science) was conducted for full-text articles published in English between 2014 and 2024, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. Randomized controlled trials comparing the effects of fibre formulas versus fibre-free formulas on adult patients receiving enteral feeding were deemed eligible. Results: Eight studies involved 640 participants aged between 18 and 90 years were identified and evaluated. Six studies demonstrated significant improvements in diarrhoea incidence in the intervention group (p < 0.05), while one study found no significant differences in diarrhoea incidence among the groups. Regarding constipation, two studies reported a significant decrease in the intervention group, whereas two studies found no significant difference in constipation rates across the groups. For secondary outcomes, two studies revealed a significant decrease in the length of hospital stay, while four studies indicated no statistically significant differences among the groups. Additionally, three studies showed an improved volume of nutrient intake (p < 0.05), while three studies reported similar mean daily intake between the groups. Conclusion: Fibre-containing enteral feeds appear to be beneficial in managing gastrointestinal symptoms, particularly diarrhoea, and may also enhance secondary outcomes, such as nutritional intake, in hospitalised patients receiving enteral feeding. However, further robust, well-designed randomized controlled trials are essential to provide definitive guidance for clinical practice. Keywords: Enteral nutrition, enteral feeding, fibre containing formula, fibre free feeds, GI symptoms, gastrointestinal symptoms25 0Item Restricted A systematic review of the use of probiotics in enteral feeding to improve enteral associated gastrointestinal symptoms(University of Nottingham, 2024) alharthi, waleed; Musson, JaneAbstract Background: Enteral nutrition is an important therapy for patients who cannot satisfy their nutritional requirements orally. However, it often leads to gastrointestinal issues such as diarrhoea, nausea, vomiting and abdominal pain. Probiotics have been suggested as a potential intervention to alleviate these symptoms, but their efficacy in this context remains unclear. The present study aimed to systematically review the impact of probiotics on gastrointestinal symptoms in adult patients receiving enteral nutrition. Methodology: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The PubMed and Medline databases were searched for English-language randomised controlled trials (RCTs) published since 2010. The search terms combined keywords related to gastrointestinal symptoms, probiotics and enteral nutrition. The reviewed studies had adult participants receiving enteral nutrition, compared probiotics with placebos and reported on gastrointestinal symptoms. The quality of the studies was assessed using the updated Cochrane risk-of-bias tool (RoB 2). Primary outcomes included changes in gastrointestinal symptoms, such as diarrhoea and nausea, while secondary outcomes covered biochemistry tests, mortality rates, length of ICU and hospital stays and BMI changes. Results: Of the 549 initially identified studies, 7 RCTs met the inclusion criteria. The results showed that probiotics were associated with a reduction in diarrhoea incidence in several studies, including significant findings from Zhao et al. (2017) and Motoori et al. (2022). Probiotics also significantly reduced vomiting and abdominal pain in specific trials, such as those conducted by Karolina et al. (2020) and Shao et al. (2013). However, the impact of probiotics on secondary outcomes, such as biochemistry tests, mortality rates and ICU and hospital stays, was limited, with no significant improvements observed in these areas. Conclusion: Probiotics appear to be beneficial in managing certain gastrointestinal symptoms associated with enteral nutrition, particularly diarrhoea and vomiting. Although some studies found significant improvements, others did not observe notable effects. The evidence supports the potential of probiotics as an adjunctive therapy in enteral nutrition management. However, further research is needed to identify the most effective probiotic strains, dosages and treatment durations to enhance overall patient outcomes.6 0