Saudi Cultural Missions Theses & Dissertations

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    Exploring the impact on family caregivers of someone living with a haematological neoplasm: systematic review
    (Queen's University Belfast, 2024-07-07) Alhindi, Razan; Quinn, Barry
    Abstract: Title: Exploring the impact on family caregivers of someone living with a haematological neoplasm. Background: Haematological neoplasms (including leukaemia, lymphomas, myelomas) present unique challenges due to their often-rapid onset, acute symptoms, and the potential for relapse. As treatment advances and overall survival improves, the number of family caregivers navigating these complexities increases. Understanding the experiences of these caregivers is crucial for further targeted support. Aim: This systematic review aims to synthesise current evidence on the impact on family caregivers of someone living with a hematological neoplasm, identifying key themes and areas for practice and future research. Methodology: Using a systematic literature review approach, evidence was synthesised on the impact on family caregivers of someone living with a hematological neoplasm. The review was conducted using three databases, CINAHL, Medline, and PsycINFO. A total of ten studies met the criteria and were included in this review. Findings: The review revealed three main themes: 1) The positive outcomes of being a family caregiver and developing coping strategies, these include strengthened family bonds, coping through better communication, and support-seeking approaches which contributed to an enhanced experience. 2) Family caregivers face significant emotional and physical disruptions, including, distress, anxiety, uncertainty, insomnia, increased tasks and frequent visits to hospital clinics. 3) Changes occur within the home and family caregivers report lack of support from health care professional and family members, this included changes in family dynamics, undertaking additional responsibilities, and financial changes. Conclusion: Family caregivers of someone living with a hematological neoplasm face complex and challenging experiences. While the role of a family caregiver is often challenging, many caregivers are able to adapt and find positive outcomes from the experience. Future practice should consider this and further research should investigate the efficacy of interventions targeting the specific needs of this population, including a more family centred approach and learning from the positive outcomes, and overcoming challenges.
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    Pediatric Oncology Nurses’ knowledge and practice in oral mucositis pain management: A Systematic Litruture Review.
    (Saudi Digital Library, 2023-11-09) ِAlotaibi, Amjad; Cardwell, Pauline
    Background: Oral mucositis, a painful and distressing side effect of cancer treatment, affects patients' ability to eat, communicate, and maintain good nutrition. In order to provide comprehensive care to these patients, nurses are integral to managing the pain associated with oral mucositis. Yet, there are concerns regarding nurses' knowledge and adherence to evidence-based practices when addressing oral mucositis-related pain. Objective: to explore knowledge and practice of oncology nurses related to the management of oral mucositis pain in children with cancer diagnosis. Method: A systematic literature search was conducted using reputable databases such as PubMed, CINAHL, and Scopus. For eligibility purposes, studies published between 2013 and 2023 were reviewed. Studies selected focused on nurses' knowledge and practices regarding pain management associated with oral mucositis through cross-sectional surveys. PRISMA chart was used to document the search process, and JBI (Joanna Briggs Institute) criteria were used to evaluate studies included in the review. PIO elements were utilized to extract the data. Result: A review of seven cross-sectional studies meeting the predetermined criteria was conducted, covering different geographical regions. As a result of the data extraction process, oncology nurses consistently exhibited limited knowledge and practice in managing oral mucositis pain. Notably, nurses exhibited deficiencies in knowledge and practice related to pharmacological interventions, oral mucositis grading, and pain management guidelines. A lack of education and training, concerns about potential side effects from medications, and inconsistencies with pain assessment methods have all contributed to inadequate pain management. Conclusion: Several critical steps are needed to improve the quality of life of cancer patients with oral mucositis. By implementing standardised protocols for managing oral mucositis pain, nurses can provide consistent and evidence-based care, which enhances patient safety and treatment effectiveness. The multidisciplinary teamwork of oncologists, specialists, and other healthcare professionals provides a holistic approach to treating patients, addressing both their physical and psychological needs. Additionally, ongoing research provides nurses with access to emerging therapies and tailored interventions for improving care and outcomes in the management of oral mucositis.
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    How well does a weight-based unfractionated heparin infusion protocol perform in adult patients during the initial dosing period
    (Saudi Digital Library, 2022-08-23) Fallatah, Osama; Patel, Jignesh; Man, Kenneth
    Background: Unfractionated heparin (UFH) has been used in clinical practice for many years and remains the agent of choice in critically unwell patients, those patients with severe renal dysfunction, and peri-procedurally during cardiac procedures. At King’s College Hospital, a new IV UFH adult guideline was introduced in Oct 2021, recommending a weight-based dosing schedule and a calibrated anti-Xa assay to monitor UFH, in place of APTT. This audit aimed to review how well the new dosing protocol performed in clinical practice during the initial dosing period. Methods: A retrospective audit was conducted of all adult patients commencing UFH infusion from the launch of the guidelines - 13th October 2021 to the 27th of January 2022. In addition to the demographic information on the patients commenced on UFH, the indication and setting of the infusion were recorded, along with the initial dosing received and whether the guidelines were followed. Descriptive statistics were used to analyse the data. Result: Ninety-seven patients were commenced on a UFH infusion during the audit period with a mean age of 60.7 years [SD +/- 14.9] and a mean first anti-Xa result of 0.63 IU/mL [SD = 0.43]. Most patients were in the ICU [n=37, 38%], renal [n=22, 23%], and cardiac ward setting [n= 14, 15%] when the UFH infusion was initiated. Sixty-seven percent [n=65] were male, with 40% prescribed the UFH infusion for venous thromboembolism. The results show that patients who had been prescribed the UFH bolus dose and followed the weight-based UFH guideline [n=16, 41%] were above the target therapeutic range. However, patients treated according to the guideline but not administered a bolus dose [n=38] were more likely to have the first anti-Xa level in the range [n=27,71%]. Female patients were more likely to be above the range [n=11, 34%] compared to male patients [n=12, 18%]. Conclusion: The new protocol using a weight-based dosing schedule and anti-Xa performed well in ensuring therapeutic levels of anticoagulation with UFH. The findings suggest that patients who were not administered the bolus and followed the UFH infusion guideline were more likely to achieve the anti-Xa therapeutic range. We have now amended our UFH guideline from mandating the bolus to considering the administration of a bolus if clinically indicated. We plan to re-audit, following this change
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