Saudi Cultural Missions Theses & Dissertations
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Item Restricted Subcellular Location-Dependent Regulation of Interferon-Induced Transmembrane Protein 1 in Glioblastoma(The University of Edinburgh, 2024) Mubarak, Rawan; Ball, KathrynGlioblastoma multiforme (GBM) is one of the most aggressive and lethal brain cancers, known for its highly invasive nature and resistance to conventional therapies. Central to this resistance is the presence of glioblastoma stem cells (GSCs), which contribute to tumour recurrence and heterogeneity. This thesis investigates the roles of interferon-induced transmembrane proteins (IFITMs), specifically IFITM1 and IFITM3, within GSCs and their potential as therapeutic targets. The study provides a detailed analysis of IFITM1’s expression, subcellular localisation, and interaction with other proteins in response to interferon stimulation, employing advanced molecular techniques such as co-immunoprecipitation, immunofluorescence microscopy, and proteomic analysis. Key findings include the discovery that IFITM3 plays a critical role in regulating IFITM1’s expression and localisation, with significant implications for IFITM1’s function in cancer cell biology. This thesis also contributes to validating a novel interaction between IFITM1 and Lysosomal-associated membrane protein 1, suggesting a potential role for IFITM1 in autophagy, which could be pivotal in GBM’s resistance to treatment. These insights not only advance the understanding of IFITM proteins in GSCs but also highlight their potential as targets for therapeutic intervention in GBM. This work lays the foundation for future studies aimed at manipulating IFITM proteins to develop novel strategies for overcoming GBM treatment resistance.46 0Item Restricted The Impact of Companies in Saudi Arabia Employing Citizens in The Private Sector, And How Does This Relate to The Development of Saudisation Under Vision 2030.(Loughborough University, 2024-03-10) Albahooth, Feras; Leite, HigorThe implementation of the Saudisation programme in Saudi Arabia has elicited considerable scholarly interest in recent years. This study examined the implementation of Saudisation policy in the private sector, the programme’s benefits and challenges, and its contributions to Vision 2030. Eight managers from private organisations were recruited through purposive sampling to participate in the study. Data from these participants were collected using semi-structured interviews and analysed through thematic analysis. The study established that while the percentage of Saudi employees in the private sector has increased substantially, their composition is skewed to non-technical fields. The findings further revealed that implementing the Saudisation policy could lead to workforce sustainability in the private industry, increased opportunities to train local talents, and allow individuals to establish and run businesses in Saudi Arabia. These benefits notwithstanding, the study uncovered various obstacles hindering the implementation of the policy among private entities. Commonly experienced hurdles include a shortage of skilled local talents, Saudi nationals’ reluctance to work in the private sector, and the inadequacy of Taqat in talent screening. Despite these challenges, the study found that the Saudisation policy can contribute to the realisation of Vision 2030 goals by alleviating unemployment rates and boosting the country’s economy fortunes through increased investments by locals. Keywords: Saudisation, localisation, Nitaqat, private sector, Saudi nationals, expatriates, Vision 203024 0