Saudi Cultural Missions Theses & Dissertations
Permanent URI for this communityhttps://drepo.sdl.edu.sa/handle/20.500.14154/10
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Item Restricted The Association Between Weight Loss and Periodontal Inflammation(Saudi Digital Library, 2023-12-01) Khoja, Fay; Suvan, JeanieBackground: Evidence reports an association between obesity and periodontal disease, however minimal research exists regarding the possible impact of weight loss through diet or bariatric surgery on periodontal condition. The aim of this study was to investigate the effect of weight loss through diet or surgery on periodontal health. Method: This study was a single centre quasi-experimental study with 6- and 12- weeks follow up recruited patients allocated to two groups; diet route and bariatric surgery route. Dental, social history, and periodontal examinations were carried out for each participant to determine their periodontal status. Masticatory function was assessed objectively (masticatory efficiency) using a validated colour-mixing chewing assessment and a validated self-reported questionnaire exploring participants oral health perception questionnaire (Dental habits, Obesity stigma in dental office, masticatory ability). Patient subsequently received bariatric surgery or a 12-week low-calorie diet. Six- and twelve-weeks following surgery or diet, the clinical and masticatory assessments were repeated. Results: This thesis will present partial findings of the ongoing study. The study recruited 7 participants living with obesity (4 in the diet group, 3 in the surgery group) all participants were recruited for baseline assessment, and 2 reported 6 weeks follow up (one from each group). The mean age in years within surgery and diet groups was 35.29 SD± 8.38, with weight mean range of 136.80 Kg SD± 10.3 and 129.53 Kg SD± 6.35 for surgery and diet groups respectively. Questionnaire analysis for obesity stigma in the dental office demonstrated 28.6% avoided dental care treatment due to feeling uncomfortable and reported that a dental care provider critiqued or insulted them regarding their weight. Conclusions: Due to the ongoing nature of this study, no conclusion can be reported regarding the influence of weight loss on the periodontal status. The self-reported questionnaire reported that one third of the enrolled participants faced discrimination related to their weight in the dental office.4 0Item Restricted The antibacterial efficacy of isolated bacteriophages against periodontal biofilms: A systematic review of in vitro studies(Saudi Digital Library, 2023-08-07) Binsaif, Nasser; Ramage, GordonBackground and aim: Periodontitis is a widespread, irreversible disease that threatens the oral health and quality of life of adult individuals. Antibiotics have been used to systemically treat periodontitis in combination with mechanical therapy, but they are increasingly resisted by the human microbiome. Phage therapy has been proposed to exhibit antibacterial activity, consequently, replace the use of antibiotic drugs. This study aimed to identify and summarise the current in vitro evidence of phage therapy’s effectiveness against periodontal biofilm. Methods: The PubMed, Web of Science, and Ovid (Embase) databases were searched to identify in vitro literature that investigated phage therapy as a treatment for periodontal biofilm using search terms referring to periodontal biofilm and bacteriophages. The literature was screened by reading the titles and abstracts to identify studies to be read fully, and inclusion and exclusion criteria were also applied. Thereafter, the included studies were processed to extract relevant study characteristics and general outcomes before performing quality assessments. Results: Ten publications were found to meet the inclusion criteria. All of these studies indicated that bacteriophages exhibited significant antibacterial activity against monospecies biofilms comprised of the micro-organisms F. nucleatum, E. faecalis, S. mutans, or A. actinomycetemcomitans. Regarding bacteriophage resistance, only one study reported resistance of E. faecalis biofilm after 24 hours, and the remaining studies did not report resistance activity. Discussion and conclusion: Recent in vitro studies suggest the use of phage therapy as a novel systemic periodontal treatment. However, a specific phage for use against P. gingivalis remains undetected. Moreover, the antibacterial efficacy of phage therapy against complex periodontal biofilms is still unclear.70 0