Novel Applications of Enhanced Raman Spectroscopy for Drug Discovery, mRNA Vaccine Stability Assessment, and Forensic Purposes

dc.contributor.advisorLednev, Igor K
dc.contributor.authorAlmehmadi, Lamyaa
dc.date.accessioned2023-08-24T09:35:58Z
dc.date.available2023-08-24T09:35:58Z
dc.date.issued2023-08-01
dc.description.abstractThe main focus of this dissertation was to apply enhanced Raman spectroscopy techniques to a variety of applications, ranging from drug discovery, mRNA vaccine stability, to forensic analysis. There are five chapters in this dissertation. The first chapter discusses the basics of enhanced Raman spectroscopy techniques and their relevance. The second chapter is focused on the use of surface-enhanced Raman spectroscopy (SERS) for drug discovery. The third chapter introduces the use of deep ultraviolet resonance Raman (DUVRR) spectroscopy for the detection of mRNA degradation in a mRNA vaccine model. The fourth chapter introduces the use of stand-off Raman spectroscopy in addition to chemometrics for the detection and identification of body fluid traces. The final chapter presents an overview of the conclusions drawn from this dissertation.
dc.format.extent77
dc.identifier.isbn9798380074452
dc.identifier.urihttps://hdl.handle.net/20.500.14154/68968
dc.language.isoen_US
dc.publisherProQuest
dc.subjectDeep ultraviolet resonance Raman Drug discovery
dc.subjectForensics
dc.subjectmRNA vaccine
dc.subjectRaman spectroscopy
dc.subjectSurface-enhanced Raman spectroscopy
dc.titleNovel Applications of Enhanced Raman Spectroscopy for Drug Discovery, mRNA Vaccine Stability Assessment, and Forensic Purposes
dc.typeThesis
sdl.degree.departmentChemistry department
sdl.degree.disciplineChemistry
sdl.degree.grantorUniversity at Albany, SUNY
sdl.degree.nameDoctor of Philosophy

Files

Copyright owned by the Saudi Digital Library (SDL) © 2025