Design, Synthesis of Some Novel Imidazopyrazole Derivatives and Assessment for Their Anti-diabetic Activity

Abstract

In general, we synthesised novel fused of 3-methyl-1-phenyl-3a,4-dihydroimidazo[4,5-c]pyrazole-5(1H)-thione ring via cyclocondensation of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one within thiourea in basic media, then we convert it into numerous derivatives such as imidazopyrazol thiourea, acetohydrazide, 5-chloro imidazopyrazol, 5-amino imidazopyrazol ,imidazopyrazol dione, propanenitrile, Mannich base, quinazolin-one, 5-hydrazinyl imidazopyrazol, tetrazole, triazin-5-ol, Schiff base and imidazopyrazol 4-nitrophenyl prop-2-en-1-one via nucleophilic substitution and addition reactions and we confirmed the structure of these compounds by analytical and spectral data (IR, 1H,13C-NMR and LC mass spectra).Moreover, sixteen of these compounds were examined for anti-diabetic activity as compared to standard drug. Some of them (II, VIII, XVI, XXIII, XXVI, XXVIII, XXXII, XXXV, XXXVI) showed a significant activity. While compounds (XI, XIII, XXX) has shown a moderate activity and compounds (V, VI, XXII, XXIV) showed a low potency. Furthermore, the present study correlate that the anti-diabetic effect of these compounds within the chemical structure.