Preparation and pharmacokinetic of azithromycin loaded polyethylene sabacte of nanoparticles in rabbits after oral and intravenous administration

Abstract

Abstract : The aims of this study is to improve the pharmacokinetics and targeting azithromycin efficiently into lung tissue as well as improve the pharmacokinetic profile of the drug through extending its half-life and improve the potency through using low dose and consequently minimizing the possible side effects of the drug in comparable with its original compound; azithromycin. The present research was involve the preparation of azithromycin nanoparticles incorporated with polyethylene sebac