Additive Effects of Turmeric Forte Supplement on Type-2 Diabetes Mellitus in Sprague Dawley Rats Fed Nauclea Latifolia Root Extracts

Abstract

Background: This study aimed to explore the antidiabetic effects of Nauclea latifolia (N. latifolia) root extracts and the additive effect of turmeric forte supplement in T2DM Sprague Dawley (SD) rats. Methodology: Over fourteen days, sixteen male SD rats were categorized into three groups: normal control, intervention group 1, and intervention group 2. All groups consumed a high-fat diet (HFD) for three weeks. Subsequently, the intervention group 1, and intervention group 2 were administered a low-dose (35 mg/Kg) injection of Streptozotocin (STZ). Intervention group 1 received N. Latifolia root extracts at a dose of 240 mg/kg, and intervention group 2 was given a combination of N. Latifolia and turmeric forte supplement, dosed at 240 mg/kg and 20 mg/kg, respectively. The normal control group was given an equivalent amount of distilled water. Results: The intervention group 2 exhibited a significant reduction in fasting blood glucose (FBG) within 2 hours of treatment (p < 0.05). The intervention group 1 displayed a steady decline in FBG levels and significant reduction was observed at timepoint 8 and the study's endpoint compared to their initial baseline. Triglyceride (TG) levels in intervention group 1 were significantly higher than those in the control group (p < 0.05). Intervention group 2 exhibited reduced total cholesterol (TC) and low-density lipoprotein (LDL) levels compared to the other groups. High-density lipoprotein (HDL) was improved in intervention group 1 and intervention group 2 compared to the normal control group, but the result was not statistically significant. Conclusion: In conclusion, the study highlights the potential benefits of herbal interventions on FBG and lipid profiles. Further research, extending over a longer duration and involving different doses, is recommended to ascertain the full impact of these interventions.