Immunological Study of some Changes in the CD Markers of Blood and Mammary Gland Cells of Cattle Naturally Infected with Paratuberculosis

Abstract

Johne’s disease (JD), caused by Mycobacterium avium subspecies. paratuberculosis (MAP), is widespread all over the world and causes significant economical losses to the dairy cattle. Control of JD has been hindered by the limited sensitivity of the diagnostic methods because of the uncovered knowledge on the biology of MAP, host immune reaction, and the pathogenesis of the disease. In this study the percentages of lymphocytes subsets (CD4+, CD8+,