Baphia Nitida Lodd - Minerals Content and Its Effect on Muscle Minerals Content in Type 2 Diabetes Sprague Dawley Rats

Abstract

Background: Medicinal plants have been utilized to manage ailments and promote good health for centuries. Selenium (Se), chromium (Chr), and magnesium (Mg) levels have been linked to the pathogenesis of type 2 diabetes mellitus (T2DM). Baphia Nitida Lodd leaf extract has been used as a traditional treatment for diabetes. This study aimed to determine the levels of selenium, chromium, and magnesium in the Baphia Nitida Lodd roots and in the musculature of T2DM rats after the administration of Baphia Nitida Lodd cord roots extracts for 21 days. Methodology: In a twenty-two -day experimental study, fifteen male Sprague Dawley rats were divided into three groups: normal control, diabetes or positive control, and intervention. All groups were given a high-fat diet. The diabetic control and intervention groups received a low-dose injection of Streptozotocin (STZ). The intervention group were given orally Baphia Nitida Lodd plant extracts once daily. The diabetic control and normal control groups received equivalent amount of distilled water orally. Se, Chr, Mg levels were analyzed in terminal thigh muscle tissues and plant extract. Result: Magnesium had the highest concentration while selenium was the lowest in the Baphia Nitida Lodd roots. There is no statistical significance in the minerals’ level in the rats’ muscles among the groups. Conclusion: The administration of Baphia Nitida Lodd roots have no impact on the minerals’ content of the muscles.