Responsive nanoprobe for redox biomolecules quantification

Abstract

Redox molecules have attracted scientific interest due to their crucial roles in regulating cellular function and maintaining redox balance. Among them, reactive oxygen species (ROS) and reactive sulfur species (RSS) are considered as highly important groups of signaling mediators. Behind their association with oxidative stress, these species critically participate in regulated redox reactions that impact diverse biological processes, including metabolism, inflammation, and cellular proliferation. Fluorescent-based nanoprobes were engineered to facilitate the monitoring of OH and H2S generation during critical biological processes, including macrophage polarization, tumor progression, and antioxidant interventions. These nanoprobes hold substantial potential to advance future research aimed at elucidating the redox dynamics underlying inflammatory responses and oncogenic transformations, thereby contributing to the development of more effective diagnostic and therapeutic strategies for related diseases.