Dental maturity in individuals born with Van der Woude syndrome and isolated cleft palate

Abstract

Objectives: To analysis and compare dental maturity (DM) in children born with Van der Woude syndrome (VWS), with age matched children born with non-syndromic isolated cleft palate (NSCP) and aged-matched non-cleft controls. Materials and methods: Dental panoramic tomography (DPT) of 204 children, consisting of 118 girls and 86 boys, divided into 51 DPT of patients born with VWS mean age 8.17 years (±1.34), 51 DPT of patients born with NSCP mean age 8.09 years (±1.41) and 102 DPT of noncleft children as control mean age 8.62 years (±1. 24). Dental stages of the seven left mandibular teeth (excluding third molars) were assessed by a method developed by Demirjian with Finnish dental maturity scoring values. Dental maturity (DM) was calculated by subtracting dental age DA from the converted chronological age CA. Statistical analysis were performed by one way ANOVA and linear regression test were used to analyze the interaction between groups and between genders. Repeatability test were determined with intra-class correlation test and 95% confidence intervals. Result: DA and CA differences in the VWS group (0.12 years) and the NSCP group (0.09 years) were significantly lower than the non-cleft group (0.40 years) (P= 0.002). However, the difference between the VWS and NSCP groups was not significant (P= 0.885). There was no significant difference between genders (P= 0.074). In the non-cleft group the DA was overestimated for both younger and older children, whereas the NSCP and VWS groups were overestimated for younger patients and underestimated for older patients. Conclusions: DA and CA differences were delayed in both VWS and NSCP groups compared to a non-cleft control. DA and CA differences of children born with VWS were at the same level of children born with NSCP.