Synthesis and characterization of some new surfactants derived from1,2,4-triazole-3-thiol.preliminary evaluation of their pharmacological activities

Abstract

Regioselective coupling of 5-(4-fluorophenyl)-2,4-dihydro-1,2,4-triazole-3-thione (127) with one or two equivalents of propargyl bromide in presence of triethylamine as catalyst gave 5-(4-fluorophenyl)-4H-1,2,4-triazole-3-thio(prop-2-yne) (132) in 90% yield. In contrast, when the propargylation was carried out in presence of sodium bicarbonate, a mixture of S,N4 149 and S,N2 -bis(propargylated) triazoles 150 was obtained in 85 % overall yield.