SACM - United Kingdom
Permanent URI for this collectionhttps://drepo.sdl.edu.sa/handle/20.500.14154/9667
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Item Restricted The Impact of Leadership Styles on Project Team Performance in Educational Settings: A Comprehensive Analysis(Saudi Digital Library, 0006-11-24) Bajabir, Anas; Barber, MartinThis study investigates the impact of leadership styles on project team performance within Nigerian university settings. The study uses a number of different studies to look at how democratic, authoritarian, and laissez-faire leadership styles affect staff morale, teamwork, and how information is shared in schools. With a systematic literature review method, this study looks in depth at how different leadership styles affect how well teams do their work. The reviews divide studies into groups based on how well they respond to two basic research questions. This helps us see how different types of leadership affect project teams in Nigerian universities in a more organised way. The results clearly show that democratic leadership is preferred in Nigerian colleges. This is because it encourages active participation, job happiness, and teamwork, all of which improve the organization's performance. Autocratic and laissez-faire styles, on the other hand, had various results. Letting things happen on their own sometimes made employees lose faith in management, while letting things happen naturally worked well in some places, like university libraries. The study finds that leaders who are open and adaptable, with a background in strategic planning and a focus on meeting the needs of the company, are the best way to get teams to work better in schools. These findings are very important for university managers, policymakers, and educational leaders in Nigeria. They show how important it is to have leadership training and development programs that promote flexible, welcoming management styles. The study also discusses about some problems, like limited access to data and differences in how institutions do things, that make it hard to use the results in other situations. The paper suggests that more research be 6 done on how customised leadership development can improve the performance and behaviour of teams in a range of academic settings.6 0Item Restricted Identification and Functional Characterization of Novel Variants Associated with Sepsis Identified by Whole Exome Sequencing(Saudi Digital Library, 0098-11-04) Alsaif, Hessa Saad; Knight, Julian; Jia, AliciaBackground Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is a leading cause of global mortality. Although sepsis is not considered a classic monogenic trait, there is strong evidence of the role of genetics in its susceptibility. Methods and Results This project uses the previously collected sepsis-affected cohort of 484 whole-exome sequenced (WES) samples to bring insights into genetics of sepsis. The two variants in GNLY gene encoding for antimicrobial peptide granulysin, NM_006433.5:c.255+2T>C and NM_006433.5:c.304C>T, have been prioritised using in silico variant pathogenicity prediction tools for further in vitro evaluation. These variants were present in three patients from sepsis cohort. The criteria for prioritisation were the rarity of the variants in non-affected population, the high impact consequences of the variants on GNLY transcripts and proteins, and the essential role of the GNLY gene as a key component of the immune response. NM_006433.5:c.304C>T variant introduces a premature stop codon and is predicted to lead to truncation of GNLY protein by third: from 148 aa to 102 aa. NM_006433.5:c.255+2T>C variant was predicted to affect splicing of exons 3-4 of GNLY transcript. The presence of the variants in three patients from the cohort in a heterozygous state has been confirmed through Sanger sequencing. In vitro ExonTrap minigene assays have confirmed that NM_006433.5:c.255+2T>C variant leads to aberrant splicing. It has been also investigated whether the two variants are presented in compound heterozygote state using cloning assay. The overall conclusion was that the variants are not likely to be present in the compound heterozygote state in two patients. Conclusion Potential of GNLY being a novel sepsis-susceptibility gene, caveats of variant pathogenicity predictions and the potential genetic mechanisms by which the two variants can contribute to the genetics of susceptibility of sepsis are further discussed.16 0