Saudi Cultural Missions Theses & Dissertations
Permanent URI for this communityhttps://drepo.sdl.edu.sa/handle/20.500.14154/10
Browse
2 results
Search Results
Item Restricted Improving and Characterising Influenza and COVID-19 vaccines(University of Sydney, 2023-10-19) Alharbi, Abdulsalam Abdullah; Kayser, VeyselThe development of safe and effective vaccinations against infectious illnesses and certain cancers that cause substantial morbidity and death is a major advancement in medicine. Vaccination, as a preventative public health measure, has clearly led to better health outcomes for people all over the globe. It is believed that vaccinations have prevented six million deaths every year (1). The need of developing a strong vaccination plan for global immunisation has been reaffirmed in the light of the COVID-19 pandemic. Safe and effective vaccines can only be developed with persistent characterisation and stable formulations. In addition, efforts are made to find solutions to problems like preserving cold chains, which are essential for keeping vaccines at their peak potency and efficacy throughout storage and shipping. The first chapter provides a general introduction to vaccinations and their background, as well as a brief synopsis of the other chapters, each of which is dedicated to one of three goals. In Chapter 2, we go deeply and exhaustively into a variety of flu-related topics (viruses and vaccines). The thesis's three aims are discussed in the following chapters. The primary objective was to find a suitable replacement for Triton X-100, which is currently used as a splitting agent in the manufacturing of split-virus influenza vaccines but is considered a "substance of very high concern" by the European Commission due to the production of harmful metabolites upon its environmental release. In Chapter 3, we see the results of an experimental study introducing an alternative to Triton X-100 that shows promise for use in the manufacturing of inactivated influenza vaccines. The second goal of this research was to conduct the first-ever evaluation of the capacity of macrocycles to stabilise influenza virus (chapter 4). Despite macrocycles' widespread use in the pharmaceutical industry, the potential of these structures to improve influenza vaccine formulations has not been investigated until recently. The third goal of this study was to investigate the effects of the stabiliser sCX[4] on the thermal stability and aggregation properties of two different COVID-19 vaccine formulations (from Pfizer and AstraZeneca). This study set out to explain how sCX[4] affects the stability and aggregation behaviour of COVID-19 vaccine formulations. This thesis presents novel experimental approaches that may improve and speed up the process of creating vaccines against influenza and COVID-19. These results help advance scientific knowledge and provide crucial insight for the development of future influenza and COVID-19 vaccines, which will assist public health initiatives throughout the world.16 0Item Restricted EXPLORING THE EFFECTS OF SOCIODEMOGRAPHICS, SELF-ASSESSED MENTAL HEALTH OUTLOOK, ATTITUDES, SUBJECTIVE NORMS, AND PERCEIVED BEHAVIORAL CONTROL ON INTENTION TO RECEIVE THE COVID-19 VACCINE.(2023-04-05) Yousef, Alqarni; Sánchez, JesúsIndividuals getting vaccinated with COVID-19 vaccines is one of the critical public health interventions to mitigate the COVID-19 pandemic. The research and development (R&D) activity to develop a vaccine against the disease has been intense across the globe since the release of the genetic sequence of SARS-CoV-2 in January 2020. Besides the COVID-19 vaccine being available and accessible, vaccine hesitancy is a critical challenge to public health programming about getting vaccinated. Therefore, increasing COVID-19 vaccine uptake among a broader cross-section of the population is an important public health priority. This study explored the impact of sociodemographic variables, self-assessed mental health outlook, and theory of planned behavior (TPB) constructs on intention to receive the COVID-19 vaccine among participants at the Nova Southeastern University (NSU) vaccination site. The theory of planned behavior (TPB) has been widely used to understand COVID-19 vaccination intention. A cross-sectional study design was used to explore the effects of sociodemographic variables, self-assessed mental health outlook, attitudes, subjective norms, and PBC as independent variables on the dependent variable, intention to receive the COVID-19 vaccine. Univariate and multivariate hierarchical logistic regression, and chi-square test. Approximately 74.8% of the participants in this study indicated that they intended to receive the COVID-19 vaccine. Therefore, understanding vaccination intentions is essential for developing promotional and educational strategies for national COVID-19 vaccination programs. The results revealed that older age, gender, feeling down, depressed, or hopeless, little interest or pleasure in doing things, not being able to stop or control worrying, normally receive vaccines, agreeing the COVID-19 vaccine should be mandatory, anybody help you make your decision to get the vaccine and try some other location before getting the vaccine was significantly associated with the intention to receive the COVID-19 vaccine. This study contributes to a better understanding of the reasons why some groups exhibit COVID-19 vaccination hesitancy. Moreover, the findings of this study can be translated into educational messages targeting groups that report lower vaccination intention. To optimize vaccine uptake, public health professionals should focus key messages on addressing factors that decrease vaccination intention.7 0