The synthesis and biological evaluation of cyclohexenone derived natural product
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Date
2023
Authors
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Journal ISSN
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Publisher
Saudi Digital Library
Abstract
Many cyclohexenone natural products, such as 2-crotonyloxymethyl-(4R,5R,6R)-
4,5,6-trihydroxycyclohex-2-enone (COTC), exhibit anti-cancer properties. Due to
their cytotoxicity towards a number of cancer cell lines, a large number of studies
have been carried out to understand their mechanisms of action as well as to
enhance their anti-cancer activities.
The aim of this project was concerned with the optimisation of the antiproliferative
activity of COTC and the synthetic drug WP1066, where we sought to link
derivatives of COTC and the synthetic drug WP1066 together with a PEG-based
linker. The cytotoxicity of a number of synthesised compounds was tested against
cancer cell lines MDA-MB231 and A549.
In addition, to help better understand the mechanism of action of these compounds
computational studies were carried out.
Description
Keywords
natural products, total synthesis, COTC, WP1066, A549 cell line, MDA-MB-231, cyclohexenone