Molecular pharmacological studies on renal sodium/glucose co-transporters inhibitors

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Mohammed Ali Fahad Alhamamah
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Saudi Digital Library
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ABSTRACT The sodium/glucose co-transporter (SGLT) inhibitors are new potent antdiabetic drugs by acting on glucose transport system in kidneys. Every day, the kidneys almost return about 180 grams of sugar into the body by reabsorption in the proximal convoluted tubules. SGLTs share in glucose reabsorption by moving glucose into the interior of renal cells. Therefore, inhibition of SGLTs will lead to marked loss of glucose into urine and aid in the control of hyperglycemia regardless the status
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