synthesis, Characterisation and Radiolabelling of Nanoparticles for applications in Medical imaging

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Nanoparticles for medical applications are on the verge of having a major impact in modern medicine. They can be radiolabelled with a range of radionuclides and the accumulation in the target tissues can be observed by positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging, which can be combined with other imaging modalities such as magnetic resonance imaging (MRI). The colloidal and structural stability of radiolabelled nanoparticles is crucial to achieve targeting and an appropriate biodistribution in vivo. This work focuses on the development of radiolabelling methodologies for nanoparticles to enhance their stability for SPECT and PET imaging. The chemical and magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) are attractive for biomedical applications. Combining the use of SPIONs as MRI contrast agents with PET or SPECT isotopes can overcome some limitations. Chelator free approaches have been used to synthesise SPIONs that show good colloidal stability with hydrodynamic sizes of ca. 73 and 58 nm. The SPIONs were radiolabelled with technetium-99m to give a SPECT/MRI contrast agent. This method reduces the number of radiochemical synthesis steps required and would allow rapid adoption into clinical pathways.