The Design and Simulation of Cooling Box for Organ on a Chip
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Date
2024
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
University of Leeds
Abstract
Organ on a Chip (OOAC) is a nanostructured design that mimic human biological functions in in -vitro
micro-environment by implanting living tissues from human organs in a semiconductor’s device in a form of brain on
a chip, Kidney on a Chip, liver on a chip, tumour on a chip, or even multi-organ on a chip and sometimes called
human on a chip. This technology is used for testing and development drugs on a real tissue outside of the human
body and avoid the ethical concerns of actual human testing and the inaccuracy in animal testing.
Figure 1 Organ on a chip design process [6]
OOAC is a form of lab on a chip (LOAC) which demonstrate microfluidic chip mimicking with high potential for
developing future microsystems in biomedical applications [5]. The micromachining technology for MEMS (Micro-
electromechanical system) is a rising research opportunity for micro-fluid manipulation to fabricate silicon structure
like micropumps, microvalves and tiny sensors [5].
Index Terms—Organ on a chip (OOAC), Peltier Cooling, Particle swarm optimization (PSO), Proportional-Integral
Derivative Control (PID), Thermoelectric Cooling, Kidney on a chip, Human on a chip, Seebeck effect, Crossover
frequency, Bode Plot, Ant Colony Optimization (ACO), Artificial Neural Network, Model Predictive Control (MPC),
Heat sin
Description
OOAC is a fusion of multiple research fields and the entire system involve multiple areas such as
microfluidic design, tissue engineering, microelectronics, stem cells and detection technology [6]. There are
various challenges in design and development of OOAC microenvironment that includes the biological
systems complexity, immune system integration, long term stability, throughput and scalability, ethical and
regulatory consideration, standardization, cost, and accessibility which means that the technology have not been
matured yet and a lot of R&D efforts need to be conducted for complete system viability. The OOAC module
need to be incubated and operated inside a special environment in a form of a biological reactor and connected
through temperature sensors, microfluidic pumps, light sensor, UV sensor, Potentiometer, thermoelectric
cooling, heat sink and electric fan. Thermoelectric cooling with Peltier module is the idea option for very
compact design and was invented in 1834 by Jean Peltier which discovered that by passing current into two
conductors, the junction will either absorb or release heat depends on the direction of the current flow with a
heating side and cooling side with allow the circulation of cold air inside the box and heat removal by heat skink
outside the bo
Keywords
OOAC, Peltier, Heat sink
Citation
for Organ on a Chip (OOAC) (2024). thesis. Ali Alhawaiji .