OPTIMISATION OF DRY COATING PROCESS TO STUDY THE IMPACT ON SURFACE PROPERTIES OF IBUPROFEN

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The isothermal dry coating process overcomes some limitations, such as using heat or solvents associated with current dry coating technologies. The objective of this study was to assess the impact of the processing parameters on the coating process. Ibuprofen was coated with xanthan gum, blanose, carrageenan, guar gum and polyox, using seven different processing parameters for each. The flowability was assessed using the angle of repose, and the coating integrity was evaluated after measuring absorbance using a UV spectrophotometer. Then, the concentrations were calculated from the calibration curve developed using a phosphate buffer with Sodium dodecyl sulphate. Dissolution studies were performed according to USP for xanthan gum-coated formulations, and the amount of drug release was determined using the UV spectrophotometric method. The results of the angle of repose showed enhanced flow properties of coated ibuprofen. For drug release, the use of gas made a minor difference in the coating efficiency of the one-step process, while more efficiently coated particles were obtained when gas was used in the first step of a two-step process. The three-step process did not show a significant distinction in coating efficiency, as the gas was applied in the second step. Coating efficiencies varied among the coating materials used, although the same processing parameters were used.

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