Determining The Pro-Apoptotic Effects of Different Flavonoids in Breast Cancer Cell Line

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The study exhibited the potential cytotoxic effects of different flavonoids in MD-MB231 cancer cells. All flavonoids were able to reduce cell proliferation significantly, and two of the three significantly increased the rate of apoptosis. BCL-2 gene expression was not significantly reduced; however, studies emphasised its importance to be regarded as a ratio to BAX. Other than improving the bioavailability of flavonoids, future studies should focus on understanding the different pathways involved in MDA-MB-231 cells, as our data suggest that other pathways are targeting cell proliferation other than apoptosis.

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