SUMOylation regulates focal adhesion dynamics in cancer cells

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dc.contributor.advisorProf. Phil Dash
dc.contributor.authorSALEM HUSSAIN SALEM ALHARETHI
dc.date2020
dc.date.accessioned2022-06-06T03:06:48Z
dc.date.available2020-05-20 08:20:28
dc.date.available2022-06-06T03:06:48Z
dc.description.abstractSUMOylation is a post-translational modification mechanism of proteins. I identified a novel role of SUMOylation in the regulation of focal adhesion proteins during cancer cell migration. I created a mutation in vinculin (FA protein) to prevent its SUMOylation and this mutation caused a significant reduction in the focal adhesions (FA) turnover rate and cancer cell migration.
dc.format.extent248
dc.identifier.other81853
dc.identifier.urihttps://drepo.sdl.edu.sa/handle/20.500.14154/67786
dc.language.isoen
dc.publisherSaudi Digital Library
dc.titleSUMOylation regulates focal adhesion dynamics in cancer cells
dc.typeThesis
sdl.degree.departmentCELL BIOLOGY
sdl.degree.grantorREADING UNIVERSITY
sdl.thesis.levelDoctoral
sdl.thesis.sourceSACM - United Kingdom
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