Porous Bioactive Glass Scaffold For Bone Regeneration

Abstract

There has been an upsurge in the demand and need for bone transplants as the world's population has grown, bone substitute materials are in high demand in the medical and dental fields. Obstacles to successful reconstruction of bone structure include those resulting from birth abnormalities, infectious or traumatic diseases, trauma, malignancies and non-union fracture. The necessity for synthetic bone substitutes has grown due to a shortage of autograft tissue, the risk of disease transmission, adverse host immunological reactions with allografts and decreased the time for bone repair. Bioactive glass is biocompatible and aids in the development of new healthy bone tissue. It has been demonstrated that adding bioactive glass to bone substitutes can improve their efficacy and bone healing characteristics to levels comparable to autografting. A porous scaffold plays an important role in tissue engineering to encourage vascular formation to the generation of new tissues and organs. Pore structures of scaffolds will facilitate cell seeding, cell penetration comparing to the non-porous scaffold. Aim: To evaluate the effectiveness of porous bioactive glass scaffolds for bone regeneration. Methodology: A systematic review of electronic databases was conducted to assess the current evidence (2013-2023) on the use of porous bioactive glass scaffolds for bone regeneration. To identified potential benefits or limitations. Conclusion: The current study has contributed to the knowledge of how bioactive glass scaffolds can be put to use in the therapy by giving a comprehensive overview of the literature on the evaluation of the bone-forming potential of three-dimensional bioactive glass porous scaffolds in bone defects. based on the evidence and arguments offered in this critique, bioactive glass can stimulate angiogenesis, a process that is essential for many uses in tissue regeneration, including neovascularization in bone regeneration.