Phylogenetic analysis of Paramyxoviridae based on the genes L, N and HN to determine gene variability.

Abstract

Abstract The Paramyxoviridae is considered to be an important source of virus infection and outbreaks in many areas around the world. Their ability to infect many types of species is high, additionally they are also capable of shifting from one host to another. This family contain many clinically important pathogens, such as, Mumps virus, Measles virus and Parainfluenza virus. Due to their global importance and the repeated events of new virus discovery that belong to the Paramyxoviridae, understanding their diversity and evolution could serve as cornerstone in rapidly discovering new threats of this virus family and attempting to minimize their danger fast. In this study, a phylogenetic analysis of 3 genes of the Paramyxovirus family is conducted, and the analyzed genes are L, N and HN. The software Mega was used for aligning the sequences and generating the phylogenetic trees. The sequences were obtained from GenBank. Following trees construction, phylogenetic analysis was carried out in order to determine how conserved and how variable they are.