A Systematic Review Of Current Evidence On Disseminated Intravascular Coagulation: Pathophysiology, Diagnosis, And Management Strategies

Abstract

Background Abstract Disseminated Intravascular Coagulation (DIC), which occurs as a result of the unregulated activation of blood clotting process, is associated with multiple complications including the pre-existing organ damage and cancer. Pathophysiology and Diagnostic Tool The Disease affects coagulation system constituents, inflammatory mediators, endothelial cells, and platelets, constituting a complex pathophysiology. Using D-dimer evaluation as the diagnostic tool, this research hypothesizes that there is a direct link among the pathophysiology, diagnostic methods, and management strategies for DIC. Method Systematic inquiry is used as a selected methodological approach to investigate the topic. PRISMA approach is used to select the relevant studies for the review Findings and Analysis The findings reveal a complex systemic association between body organs and blood clotting failure. Further according to the literature findings, a complex systemic pathophysiological structure of DIC hinders the understanding of a single course of infection and progression, complicating its morbid physiology. Conclusion The possible diagnostic levels include organ failure, massive bleeding, bleeding, and non- symptomatic forms. Available evidence suggests multiple treatment options and management strategies in an attempt to minimize the severity of DIC.