The association between inflammatory bowel disease and vitamin D deficiency among adults

Abstract

Background: this research examines the association between Vitamin D supplements and Inflammatory Bowel Disease (IBD). This includes the effect of Vitamin D on the development of Ulcerative Colitis (UC) and Crohn Disease (CD) amongst adults.

Objectives: This study aims to systematically review the effect of Vitamin D on IBD in adults.

Methodology: This study applied systematic review and implemented Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. As such, consecutive steps have been followed such as determining which research databases to search (PubMed, Google Scholar and Cochrane Library), inclusion and exclusion criteria, and data extraction based on Population, Intervention, Comparison, and Outcome (PICO). The Critical Appraisal Skills Programme (CASP) Checklist, was used to perform a quality assessment of each study.

Results: The data was gathered from 6 core studies published between 2010 and 2020. Four main themes were discussed (age and gender, intervention duration, vitamin D supplement dose, and IBD biomarkers). All studies found increasing intervention duration and vitamin D doses would affect IBD biomarkers. Nevertheless, none of the studies specified moderating role of age and gender.

Conclusion: The difference in the findings amongst the studies included suggest that there should be further examination on the role of moderating or confounding factors, such as participates medial background when conducting each study.

Keywords: Vitamin D, Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Adults.