Measuring regional changes in the cerebral metabolic rate of oxygen (CMRO2) between Hypoxia and Normoxia

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Hypoxia causes a large-scale regional change in cerebral blood flow (CBF). However, it is not clear whether these changes in CBF reflect changes in metabolism. To investigate these changes, we used a developing technique called Quantitative susceptibility mapping (QSM) to look at the change in sort of cerebral metabolic rate of oxygen (CMRO2) in normoxia and hypoxia conditions as well as to measure the percentage change in Oxygen extraction fraction (OEF). To measure potential changes in CMRO2, we generated QSM images using SEPIA toolbox in MATLAB for both normoxia and hypoxia. Then, Arterial spin labeling (ASL) perfusion images to measure condition specific resting CBF. Through generating delta CBF and OEF images (subtracting the between each condition) then combing the two, we produced a surrogate measure of change in CMRO2 between normoxia and hypoxia. Our analysis indicates that the vast majority of the brain across 10 participants show no significant changes in CMRO2 between the two conditions. However, there were small clusters show a slight change in the Superior Parietal Lobule, Precuneus Cortex, and the Middle Frontal Gyrus. We conclude that when OEF is increased and blood flow is decreased during Hypoxia, CMRO2 is maintained to the same level.

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