Defining the sperm and seminal plasma effects on offspring metabolic health

Thumbnail Image

Date

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Backgrounds: This study believes that parent diets and health could associated with embryo programming development. Thus, could effect on offspring long-term health. Previous studies enhanced the concept of developmental programming because of the Barker hypothesis of foetal origin of adult diseases. It has been known that maternal diets correlate directly to offspring health. Furthermore, studies suggest that maternal health and welfare especially at the time of pregnancy may affect offspring long-term cardiometabolic health. DOHaD hypothesis suggest that the developing organism might seek to adapt into the environments in many techniques such as maternal diets. However, it could provoke unfavourable growth circumstances, both physically and functionally. On the other hand, father diets could impact on sperm and seminal plasma qualities. Therefore, sperm could play a role in embryo developing. However, it was believed that the seminal plasma only worked as a vehicle for sperms. Surprisingly, studies suggest that seminal plasma play a critical role for embryo development also offspring heath. Results: Male offspring weight (NL, LN and LL) were significant increasing during the 16 more than the control group (NN). Comparing male offspring NL and LL with males control group at 30 after bolus the responses are significant high. While, in male LN and female (NL & LL) offspring are slightly high comparing with their controls. Furthermore, the outcomes show a high gene expression of Adipor1, Akt2, Srebp, and Sirt1 in NL and LN offspring. Conclusions: This paper indicates that the seminal plasma is more than a vehicle that just deliver sperm, but also it has more important role. Additionally, sperms quality and epigenetic status influence early embryo phase development. Thus, effect on offspring health. Furthermore, father’s diet could impact on the offspring gene expression Adipor1, Akt2, Srebp, and Sirt1, which it is impact on the offspring metabolic health.

Description

Keywords

Citation

Endorsement

Review

Supplemented By

Referenced By

Copyright owned by the Saudi Digital Library (SDL) © 2025