Understanding the biology of the CTLA-4 pathway
| dc.contributor.advisor | David Sansom | |
| dc.contributor.author | MARAM FAISAL MOHAMMED ALREHAILI | |
| dc.date | 2021 | |
| dc.date.accessioned | 2022-05-28T19:56:33Z | |
| dc.date.available | 2022-05-28T19:56:33Z | |
| dc.degree.department | Infection and immunity | |
| dc.degree.grantor | University college London | |
| dc.description.abstract | Cytotoxic T lymphocyte antigen (CTLA-4), ubiquitously expressed on activated and regulatory T-cells, is an important regulator of T-cell stimulation and proliferation that functions in opposition to CD28. CD28 is deprived of stimulus by CTLA-4 modulating its interactions with its ligands, CD80 and CD86, in a process termed trans-endocytosis (TE). This results in CTLA-4 physically removing CD80 and CD86 from antigen-presenting cells. CD80 and CD86 are transmembrane glycoproteins that are mostly interchangeably defined and predominantly expressed on antigen-presenting cells. | |
| dc.identifier.uri | https://drepo.sdl.edu.sa/handle/20.500.14154/39989 | |
| dc.language.iso | en | |
| dc.title | Understanding the biology of the CTLA-4 pathway | |
| sdl.thesis.level | Master | |
| sdl.thesis.source | SACM - United Kingdom |